A pharmacogenetics study to predict outcome in patients receiving anti-VEGF therapy in age related macular degeneration.
Clin Ophthalmol
; 7: 1987-93, 2013.
Article
en En
| MEDLINE
| ID: mdl-24143065
ABSTRACT
PURPOSE:
To ascertain whether single nucleotide polymorphisms (SNPs) in the Vascular Endothelial Growth factor (VEGFA), Complement Factor H (CFH), and LOC387715 genes could predict outcome to anti-VEGF therapy for patients with age related macular degeneration (AMD).METHODS:
Patients with "wet" AMD were identified by chart review. Baseline optical coherence tomography (OCT) and visual acuity (VA) data, and at least 6 months of clinical follow up after 3 initial monthly injections of bevacizumab or ranibizumab were required for inclusion. Based on OCT and VA, patients were categorized into two possible clinicaloutcomes:
(a) responders and (b) non-responders. DNA was extracted from saliva and genotyped for candidate SNPs in the VEGFA, LOC387715, and CFH genes. Clinical outcomes were statistically compared to patient genotypes.RESULTS:
101 patients were recruited, and one eye from each patient was included in the analysis. 97% of samples were successfully genotyped for all SNPs. We found a statistically significant association between the LOC387715 A69S TT genotype and outcome based on OCT.CONCLUSION:
Genetic variation may be associated with outcome in patients receiving anti-VEGF therapy.
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Base de datos:
MEDLINE
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Clin Ophthalmol
Año:
2013
Tipo del documento:
Article