Radical [3 + 2]-annulation of divinylcyclopropanes: rapid synthesis of complex meloscine analogs.
Org Lett
; 16(1): 94-7, 2014 Jan 03.
Article
en En
| MEDLINE
| ID: mdl-24313360
ABSTRACT
A radical [3 + 2]-divinylcyclopropane annulation cascade has been extended to encompass five D-ring variants of the meloscine/epimeloscine core structure. Representative ABCD tetracyclic intermediates were further elaborated with novel substituted E-rings through subsequent transformations of advanced intermediates that provided opportunities for late-stage variation of the B-ring (lactam) N-substituents which were also developed.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Compuestos Policíclicos
/
Quinolinas
/
Ciclopropanos
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos