Spermidine improves fear memory persistence.
Eur J Pharmacol
; 730: 72-6, 2014 May 05.
Article
en En
| MEDLINE
| ID: mdl-24630833
ABSTRACT
Persistence is the most characteristic attribute of long-term memory (LTM). For memory persistence, a second late event of consolidation, that occurs around 12h after the acquisition, is necessary. Although the N-methyl-d-aspartate (NMDA) receptor has been involved in the persistence of memory, whether endogenous modulators of the NMDA receptor actually modulate memory persistence is unknown. In the current study we investigated whether spermidine and arcaine, respectively agonist and antagonist of polyamine binding site at NMDA receptor, alter the persistence of the memory of contextual fear conditioning task in rats. While 12h post-training administration of spermidine (10 and 30mg/kg, i.p.) facilitated, arcaine (10mg/kg, i.p.) impaired the memory of fear assessed 2 and 7 days after training. Arcaine (0.1mg/kg) prevented the facilitatory effect of spermidine (10mg/kg, i.p.), and spermidine (1mg/kg), prevented the memory impairment induced by arcaine (10mg/kg, i.p.) when tested 2 and 7 days after training. These results suggest that endogenous polyamines improve the persistence of fear memory.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Espermidina
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Miedo
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Memoria
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil