Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility.

Procaccia, Vera; Nakayama, Hironao; Shimizu, Akio; Klagsbrun, Michael

Procaccia, Vera; Nakayama, Hironao; Shimizu, Akio; Klagsbrun, Michael.

Afiliación

Procaccia V; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Nakayama H; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States; Graduate School of Medicine & Proteo-Medicine Research Center, Ehime Universi
Shimizu A; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Klagsbrun M; Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, United States; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Bost

Biochem Biophys Res Commun ; 448(2): 134-8, 2014 May 30.

Article en En | MEDLINE | ID: mdl-24759231

Asunto(s)

Benzamidas/farmacología; Citoesqueleto/efectos de los fármacos; Células Endoteliales/efectos de los fármacos; Piperazinas/farmacología; Inhibidores de Proteínas Quinasas/farmacología; Proteínas Tirosina Quinasas/antagonistas & inhibidores; Pirimidinas/farmacología; Semaforina-3A/metabolismo; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Citoesqueleto/metabolismo; Células Endoteliales/citología; Proteínas Activadoras de GTPasa/metabolismo; Glioblastoma/tratamiento farmacológico; Glioblastoma/metabolismo; Glioblastoma/patología; Células Endoteliales de la Vena Umbilical Humana/efectos de los fármacos; Humanos; Mesilato de Imatinib; Proteínas Tirosina Quinasas/metabolismo; Semaforina-3A/genética

Palabras clave

ABL2; Cell migration; Cytoskeletal collapse; Gleevec; Semaphorin; Stress fibers

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piperazinas / Pirimidinas / Benzamidas / Citoesqueleto / Proteínas Tirosina Quinasas / Semaforina-3A / Células Endoteliales / Inhibidores de Proteínas Quinasas Límite: Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

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