PEG spacers of different length influence the biological profile of bombesin-based radiolabeled antagonists.

Jamous, Mazen; Tamma, Maria L; Gourni, Eleni; Waser, Beatrice; Reubi, Jean C; Maecke, Helmut R; Mansi, Rosalba

Jamous, Mazen; Tamma, Maria L; Gourni, Eleni; Waser, Beatrice; Reubi, Jean C; Maecke, Helmut R; Mansi, Rosalba.

Afiliación

Jamous M; Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Tamma ML; Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
Gourni E; Department of Nuclear Medicine, University Hospital Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany.
Waser B; Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Murtenstrasse 31, CH-3010 Berne, Switzerland.
Reubi JC; Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, Murtenstrasse 31, CH-3010 Berne, Switzerland.
Maecke HR; Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland; Department of Nuclear Medicine, University Hospital Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany.
Mansi R; Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland; Department of Nuclear Medicine, University Hospital Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany. Electronic address: rosalba.mansi@uniklinik-freiburg.de.

Nucl Med Biol ; 41(6): 464-70, 2014 Jul.

Article en En | MEDLINE | ID: mdl-24780298

Asunto(s)

Aminoácidos/química; Aminoácidos/farmacología; Bombesina/antagonistas & inhibidores; Polietilenglicoles/química; Aminoácidos/metabolismo; Aminoácidos/farmacocinética; Animales; Transporte Biológico; Línea Celular Tumoral; Quelantes/química; Estabilidad de Medicamentos; Femenino; Fluorenos/química; Compuestos Heterocíclicos con 1 Anillo/química; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Ratones; Receptores de Bombesina/metabolismo; Relación Estructura-Actividad; Distribución Tisular

Palabras clave

Bombesin antagonist; Gastrin-releasing peptide receptor; PEG spacers; Prostate cancer; Radiolabeled peptides

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Polietilenglicoles / Bombesina / Aminoácidos Límite: Animals / Female / Humans Idioma: En Revista: Nucl Med Biol Asunto de la revista: BIOLOGIA / MEDICINA NUCLEAR Año: 2014 Tipo del documento: Article País de afiliación: Suiza

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