Increased survival among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals.
AIDS
; 28(7): 949-57, 2014 Apr 24.
Article
en En
| MEDLINE
| ID: mdl-24812673
OBJECTIVE: To compare survival times of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals. DESIGN: Prospective open cohort study. METHODS: We analysed data from 259 HIV-1-seroincident cases (either HIV-1 single or HIV-1 and HIV-2 dual-infected) from a cohort with long follow-up (~20 years) in order to study the influence of type of infection and infection order on mortality. Sex and age at HIV-1 infection date was controlled for in a Cox proportional-hazards model. RESULTS: Dual-infected individuals had a 42% longer time from HIV-1 infection to death compared with single-infected individuals, adjusting for age asymmetries between groups. Dual-infected individuals with an HIV-2 infection preceding the HIV-1 infection had a more than two-fold lower mortality risk during follow-up than HIV-1 single-infected individuals. CONCLUSION: Survival time is longer and the risk of progression to death is lower among HIV-1 and HIV-2 dual-infected individuals compared to HIV-1 single-infected individuals. This natural inhibition could have implications for the development of future HIV-1 vaccines and therapeutics.
Buscar en Google
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
VIH-1
/
VIH-2
/
Coinfección
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
AIDS
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
2014
Tipo del documento:
Article