Primary cilia in pancreatic development and disease.
Birth Defects Res C Embryo Today
; 102(2): 139-58, 2014 Jun.
Article
en En
| MEDLINE
| ID: mdl-24864023
ABSTRACT
Primary cilia and their anchoring basal bodies are important regulators of a growing list of signaling pathways. Consequently, dysfunction in proteins associated with these structures results in perturbation of the development and function of a spectrum of tissue and cell types. Here, we review the role of cilia in mediating the development and function of the pancreas. We focus on ciliary regulation of major pathways involved in pancreatic development, including Shh, Wnt, TGF-ß, Notch, and fibroblast growth factor. We also discuss pancreatic phenotypes associated with ciliary dysfunction, including pancreatic cysts and defects in glucose homeostasis, and explore the potential role of cilia in such defects.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Páncreas
/
Cilios
/
Organogénesis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Birth Defects Res C Embryo Today
Asunto de la revista:
EMBRIOLOGIA
/
TERATOLOGIA
Año:
2014
Tipo del documento:
Article