A determination of the current causes of hyperkalaemia and whether they have changed over the past 25 years.
Acta Clin Belg
; 69(4): 280-4, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-24942977
ABSTRACT
OBJECTIVE:
Hyperkalaemia is a potentially lethal electrolyte disorder. The objective of this study was to determine if the causes of hyperkalaemia-related visits to the emergency department (ED) have changed since 25 years.METHODS:
All patients presenting to the ED with hyperkalaemia between January 2009 and August 2011 were included in this retrospective, single-centre study. Patients were divided into one of these three categories mild (5·2≤ K(+)<5·8 mEq/l), moderate (5·8≤K(+)<7·0 mEq/l) or severe hyperkalaemia (K(+)≥7·0 mEq/l). The causes of hyperkalaemia were divided into three groups renal failure (RF), potassium-increasing drugs (PIDs) or others.RESULTS:
Overall, 139 patients with hyperkalaemia were included in the study (mean K(+) of 6·2 mEq/l) 35% with mild, 49% with moderate and 16% with severe hyperkalaemia. Eighty-three per cent of patients (nâ=â115) had RF with creatinine levels ≥1·25 mg/dl or estimated glomerular filtration rate (eGFR) levels ≤60 ml/min/1·73 m(2). Serum potassium levels were significantly related with creatinine and eGFR values (P<0·001). The severity of hyperkalaemia was significantly related with creatinine levels ≥1·25 mg/dl (Pâ=â0·002) and eGFR values ≤60 ml/min/1·73 m(2) (Pâ=â0·005). Seventy-five per cent of patients (nâ=â105) were taking PIDs. Potassium levels were significantly related with PIDs (P<0·001), in particularly spironolactone (Pâ=â0·001) and angiotensin-converting enzyme inhibitors (Pâ=â0·008). The category 'others' included 7% of patients (nâ=â10).CONCLUSIONS:
RF (83%) and PIDs (75%) remain common causes of hyperkalaemia. Hyperkalaemia is significantly related with four variables creatinine levels, spironolactone, ACEIs and beta-blocker intake. The causes of hyperkalaemia have not changed in recent years.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Hiperpotasemia
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Acta Clin Belg
Año:
2014
Tipo del documento:
Article