Functionalization, cyclization and antiviral activity of A-secotriterpenoids.
Eur J Med Chem
; 83: 601-8, 2014 Aug 18.
Article
en En
| MEDLINE
| ID: mdl-24997292
ABSTRACT
Triterpene derivatives with an α,ß-alkenenitrile moiety in the five-membered ring A have been synthesized by nitrile anion cyclizations of 1-cyano-2,3-secotriterpenoids. Oxime-containing precursors, 2,3-secointermediates and five-membered ring A products of cyclizations were screened for in vitro antiviral activity against enveloped viruses - influenza A virus and human immunodeficiency virus type I (HIV-1). Lupane ketoxime and the 2,3-secolupane C-3 aldoxime which possess antiviral activities against both influenza A virus (EC50 12.9-18.2 µM) and HIV-1 (EC50 0.06 µM) were the most promising compounds.
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Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Terpenos
Idioma:
En
Revista:
Eur J Med Chem
Año:
2014
Tipo del documento:
Article