Synthesis, reactivity and biological activity of N(4)-boronated derivatives of 2'-deoxycytidine.
Bioorg Med Chem
; 22(15): 3906-12, 2014 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-24999002
ABSTRACT
By seeking new stable boron-containing nucleoside derivatives, potential BNCT boron delivery agents, a novel synthetic approach was tested, aimed at a boron attachment via a single bond to an aliphatic carbon of sp(3) hybridization. The latter allowed successful modification of deoxycytidine in the reaction with 2-(iodomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane of the deoxynucleoside amino group. For new compounds, detailed NMR, LDI HRMS (Laser Desorption/Ionization High-Resolution Mass Spectrometry) analyses along with in vivo phosphorylation studies, toxicity assays and DFT modelling are presented.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Boro
/
Desoxicitidina
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Polonia