The correlation between renal function and bone mineral density.
Minerva Urol Nefrol
; 66(3): 153-6, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-25072129
ABSTRACT
AIM:
The moderate, severe chronic kidney disease (CKD) and end stage renal disease (ESRD) are well-recognized risk factors of bone loss. However, it is uncertain whether mild CKD stage affects bone mineral density (BMD). The objective of this study is to investigate whether mild and/or more severe reduction of GFR is associated with BMD decreasing.METHODS:
Between April and November 2011, 305 patients were included in this study. Estimated glomerular filtration rate (GFR) was calculated by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. According to the GFR, we divided the participants into 3 groups CKD stage I, stage II and stage ≥III. BMD was compared between different groups.RESULTS:
Eighty-one women and 65 men were enrolled in the final study. The average age was 65.6. According to the eGFR, 54 (37.0%), 70 (47.9%) and 22 (15.1%) participants were classified into CKD stage I, II and ≥III, respectively. The mean T-score was -1.351±1.879.A significant bone loss was found in the stage ≥III group, especially in women (P<0.05). BMD decreasing was found significantly in male participants with CKD stage II (P=0.041).CONCLUSION:
BMD significantly decreased in men with mild renal dysfunction. A significant BMD decreasing was also found in the group of CKD stage ≥III, especially in women. We suggest osteoporosis screening is necessary in patients with poor renal function.
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Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Densidad Ósea
/
Insuficiencia Renal Crónica
/
Riñón
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Minerva Urol Nefrol
Asunto de la revista:
NEFROLOGIA
/
UROLOGIA
Año:
2014
Tipo del documento:
Article