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Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.
Su, Zhaoming; Zhang, Yongjie; Gendron, Tania F; Bauer, Peter O; Chew, Jeannie; Yang, Wang-Yong; Fostvedt, Erik; Jansen-West, Karen; Belzil, Veronique V; Desaro, Pamela; Johnston, Amelia; Overstreet, Karen; Oh, Seok-Yoon; Todd, Peter K; Berry, James D; Cudkowicz, Merit E; Boeve, Bradley F; Dickson, Dennis; Floeter, Mary Kay; Traynor, Bryan J; Morelli, Claudia; Ratti, Antonia; Silani, Vincenzo; Rademakers, Rosa; Brown, Robert H; Rothstein, Jeffrey D; Boylan, Kevin B; Petrucelli, Leonard; Disney, Matthew D.
Afiliación
  • Su Z; Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #3A1, Jupiter, FL 33458, USA.
  • Zhang Y; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Gendron TF; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Bauer PO; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Chew J; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Yang WY; Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #3A1, Jupiter, FL 33458, USA.
  • Fostvedt E; Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #3A1, Jupiter, FL 33458, USA.
  • Jansen-West K; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Belzil VV; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Desaro P; Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Johnston A; Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Overstreet K; Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Oh SY; Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
  • Todd PK; Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
  • Berry JD; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02115, USA.
  • Cudkowicz ME; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02115, USA.
  • Boeve BF; Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
  • Dickson D; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Floeter MK; Spasticity and Spinal Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
  • Traynor BJ; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
  • Morelli C; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Via Zucchi, 18, 20095 Cusano Milanino (Milan), Italy.
  • Ratti A; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Via Zucchi, 18, 20095 Cusano Milanino (Milan), Italy; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Via Sforza, 35, 20122, Milan, Italy.
  • Silani V; Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Via Sforza, 35, 20122, Milan, Italy; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • Rademakers R; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Brown RH; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
  • Rothstein JD; Department of Neurology, Brain Science Institute, Johns Hopkins University, 855 N Wolfe Street, Baltimore, MD 21205, USA.
  • Boylan KB; Department of Neurology, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA.
  • Petrucelli L; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Rd., Jacksonville, FL 32224, USA. Electronic address: petrucelli.leonard@mayo.edu.
  • Disney MD; Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #3A1, Jupiter, FL 33458, USA. Electronic address: disney@scripps.edu.
Neuron ; 83(5): 1043-50, 2014 Sep 03.
Article en En | MEDLINE | ID: mdl-25132468
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores / Proteínas / Expansión de las Repeticiones de ADN / G-Cuádruplex / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Biomarcadores / Proteínas / Expansión de las Repeticiones de ADN / G-Cuádruplex / Esclerosis Amiotrófica Lateral Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos