Absence of the human CYP2C8*3 allele in Ugandan children exposed to Plasmodium falciparum malaria.
Infect Genet Evol
; 27: 432-5, 2014 Oct.
Article
en En
| MEDLINE
| ID: mdl-25183026
ABSTRACT
Study of host pharmacogenetics can improve our knowledge of mechanisms of drug resistance selection and spread. This issue has recently been addressed with respect to chloroquine and amodiaquine in malaria endemic areas of West and East Africa. Here we report, from surveys performed in two different areas of Uganda, that the human CYP2C8*3 allele, which had been reported to be strongly associated with parasite drug resistance in Zanzibar, is absent, being a marker of genetic admixture of the Zanzibari population with a Caucasoid component. Moreover, a retrospective analysis of CYP2C8*2 and the Plasmodium falciparum drug resistant pfmdr1 86Y allele does not show any association, which may be related to the high level of drug resistance.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Malaria Falciparum
/
Predisposición Genética a la Enfermedad
/
Alelos
/
Citocromo P-450 CYP2C8
Límite:
Child
/
Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
Infect Genet Evol
Asunto de la revista:
BIOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
GENETICA
Año:
2014
Tipo del documento:
Article