Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.

Foijer, Floris; Xie, Stephanie Z; Simon, Judith E; Bakker, Petra L; Conte, Nathalie; Davis, Stephanie H; Kregel, Eva; Jonkers, Jos; Bradley, Allan; Sorger, Peter K

Foijer, Floris; Xie, Stephanie Z; Simon, Judith E; Bakker, Petra L; Conte, Nathalie; Davis, Stephanie H; Kregel, Eva; Jonkers, Jos; Bradley, Allan; Sorger, Peter K.

Afiliación

Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV, Groningen, The Netherlands; Department of Systems Biology, Harvard Medical School, Boston, MA 02115; Mouse Genomics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Uni
Xie SZ; Department of Systems Biology, Harvard Medical School, Boston, MA 02115;
Simon JE; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV, Groningen, The Netherlands;
Bakker PL; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, NL-9713 AV, Groningen, The Netherlands;
Conte N; Mouse Genomics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom; and.
Davis SH; Department of Systems Biology, Harvard Medical School, Boston, MA 02115;
Kregel E; Division of Molecular Pathology, The Netherlands Cancer Institute, NL-1066 CX, Amsterdam, The Netherlands.
Jonkers J; Division of Molecular Pathology, The Netherlands Cancer Institute, NL-1066 CX, Amsterdam, The Netherlands.
Bradley A; Mouse Genomics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom; and.
Sorger PK; Department of Systems Biology, Harvard Medical School, Boston, MA 02115; f.foijer@umcg.nl peter_sorger@hms.harvard.edu.

Proc Natl Acad Sci U S A ; 111(37): 13427-32, 2014 Sep 16.

Article en En | MEDLINE | ID: mdl-25197064

Asunto(s)

Aneuploidia; Inestabilidad Cromosómica/genética; Mutación/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/patología; Proteínas Serina-Treonina Quinasas/genética; Estrés Fisiológico/genética; Proteína p53 Supresora de Tumor/genética; Animales; Aberraciones Cromosómicas; Células Clonales; Dosificación de Gen; Regulación Leucémica de la Expresión Génica; Heterocigoto; Humanos; Cariotipificación; Puntos de Control de la Fase M del Ciclo Celular/genética; Ratones; Proteínas Serina-Treonina Quinasas/química; Estructura Terciaria de Proteína; Transcripción Genética

Palabras clave

CIN; T-cell acute lymphoblastic lymphoma; chromosomal instability; mouse models; tumor metabolism

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Proteína p53 Supresora de Tumor / Proteínas Serina-Treonina Quinasas / Inestabilidad Cromosómica / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Aneuploidia / Mutación Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2014 Tipo del documento: Article

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