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Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.
Takakusagi, Yoichi; Matsumoto, Shingo; Saito, Keita; Matsuo, Masayuki; Kishimoto, Shun; Wojtkowiak, Jonathan W; DeGraff, William; Kesarwala, Aparna H; Choudhuri, Rajani; Devasahayam, Nallathamby; Subramanian, Sankaran; Munasinghe, Jeeva P; Gillies, Robert J; Mitchell, James B; Hart, Charles P; Krishna, Murali C.
Afiliación
  • Takakusagi Y; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Matsumoto S; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Saito K; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Matsuo M; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Kishimoto S; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Wojtkowiak JW; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.
  • DeGraff W; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Kesarwala AH; Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Choudhuri R; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Devasahayam N; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Subramanian S; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Munasinghe JP; National Institute of Neurological Diseases and Stroke, Bethesda, Maryland, United States of America.
  • Gillies RJ; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America.
  • Mitchell JB; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
  • Hart CP; Threshold Pharmaceuticals, South San Francisco, California, United States of America.
  • Krishna MC; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.
PLoS One ; 9(9): e107995, 2014.
Article en En | MEDLINE | ID: mdl-25254649
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Mostazas de Fosforamida / Profármacos / Ácido Pirúvico / Mitocondrias / Antineoplásicos / Nitroimidazoles Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Consumo de Oxígeno / Mostazas de Fosforamida / Profármacos / Ácido Pirúvico / Mitocondrias / Antineoplásicos / Nitroimidazoles Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos