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IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.
Shimizu, Takatsune; Sugihara, Eiji; Yamaguchi-Iwai, Sayaka; Tamaki, Sakura; Koyama, Yuko; Kamel, Walied; Ueki, Arisa; Ishikawa, Tomoki; Chiyoda, Tatsuyuki; Osuka, Satoru; Onishi, Nobuyuki; Ikeda, Hiroko; Kamei, Junzo; Matsuo, Koichi; Fukuchi, Yumi; Nagai, Toshihiro; Toguchida, Junya; Toyama, Yoshiaki; Muto, Akihiro; Saya, Hideyuki.
Afiliación
  • Shimizu T; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan. Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. CREST, Japan Science and Technology Agency
  • Sugihara E; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. CREST, Japan Science and Technology Agency, Tokyo, Japan.
  • Yamaguchi-Iwai S; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Tamaki S; Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.
  • Koyama Y; Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.
  • Kamel W; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan. Laboratory of Cell and Tissue Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Faculty of Science, Mansoura University, Mansoura, Egypt.
  • Ueki A; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Ishikawa T; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Kasai R&D Center, Daiichi Sankyo Co. Ltd., Tokyo, Japan.
  • Chiyoda T; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Osuka S; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Onishi N; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Ikeda H; Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.
  • Kamei J; Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.
  • Matsuo K; Laboratory of Cell and Tissue Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Fukuchi Y; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.
  • Nagai T; Electron Microscopy Laboratory, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Toguchida J; Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan. Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Sakyo-ku, Kyoto, Japan. Department of Orthopaedic Surgery, Kyoto Univer
  • Toyama Y; Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
  • Muto A; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.
  • Saya H; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. CREST, Japan Science and Technology Agency, Tokyo, Japan. t-shimizu@hoshi.ac.jp hsaya@a5.keio.jp.
Cancer Res ; 74(22): 6531-41, 2014 Nov 15.
Article en En | MEDLINE | ID: mdl-25273088
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Autofagia / Neoplasias Óseas / Factor II del Crecimiento Similar a la Insulina / Osteosarcoma Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Autofagia / Neoplasias Óseas / Factor II del Crecimiento Similar a la Insulina / Osteosarcoma Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male Idioma: En Revista: Cancer Res Año: 2014 Tipo del documento: Article