New 19-oxygenated steroid from the South China Sea gorgonian Dichotella gemmacea.
Nat Prod Res
; 29(2): 169-73, 2015.
Article
en En
| MEDLINE
| ID: mdl-25350498
ABSTRACT
A new 19-oxygenated steroid, 25-acetate-nebrosteroid K (1), and five known steroids (2-6), along with one known 19-hydroxy steroidal glycoside (7) were obtained from the gorgonian Dichotella gemmacea collected from the South China Sea. The structure and relative configuration of 1 were elucidated by using comprehensive spectroscopic data including NOESY spectra. Compound 1 represents the first example of 19-oxygenated steroid with a 19-oic acid methyl ester group isolated from gorgonians. All of the isolated compounds were evaluated for lethal activity to brine shrimp Artemia salina and cytotoxicity against A549 and HL-60 cell lines. Among them, 1 showed strong lethality towards A. salina.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Esteroides
/
Antozoos
Límite:
Animals
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Año:
2015
Tipo del documento:
Article