DNA barcoding of clinically relevant Cunninghamella species.
Med Mycol
; 53(2): 99-106, 2015 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-25431472
ABSTRACT
Mucormycosis caused, in part, by representatives of the genus Cunninghamella is a severe infection with high mortality in patients with impaired immunity. Several species have been described in the literature as etiologic agents. A DNA barcoding study using ITS rDNA and tef-1α provided concordance of molecular data with conventional characters. The currently accepted Cunninghamella species were well supported in phylogenetic trees of both markers except for C. septata with ITS that clustered in the C. echinulata clade. Sequence variability was distinctly higher for the ITS than for tef-1α. Intraspecific ITS variability of some of the species exceeded that between some closely related species, but the marker remained applicable for species identification. The most variable species for both markers was C. echinulata. Cunninghamella bertholletiae is the main pathogenic species; infections by C. blakesleeana, C. echinulata, and C. elegans are highly exceptional.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Cunninghamella
/
Código de Barras del ADN Taxonómico
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Med Mycol
Asunto de la revista:
MEDICINA VETERINARIA
/
MICROBIOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Países Bajos