Endoplasmic reticulum stress is induced in the human placenta during labour.
Placenta
; 36(1): 88-92, 2015 Jan.
Article
en En
| MEDLINE
| ID: mdl-25434970
ABSTRACT
Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to labour represents an in vivo model for the study of acute placental ER stress. ER stress markers, GRP78, P-eIF2α and XBP-1, were significantly higher in laboured placentas than in Caesarean-delivered controls localised mainly in the syncytiotrophoblast. The similarities to changes observed in PE/IUGR placentas suggest exposure to labour can be used to investigate induction of ER stress in pathological placentas.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Trabajo de Parto
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Parto
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Estrés del Retículo Endoplásmico
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Placenta
Año:
2015
Tipo del documento:
Article