Minifish shows high genetic variation in mtDNA size.
Curr Mol Med
; 14(10): 1308-13, 2014.
Article
en En
| MEDLINE
| ID: mdl-25470287
ABSTRACT
The genus Paedocypris is a newly described taxon of minifish species that are characterized by extensive chromosome evolution and one of the smallest known vertebrate nuclear genomes. Paedocypris features a tiny adult size, a short generation time, low fecundity and fragmented tropical habitats, which are factors that favor rapid speciation. Most recently, we have revealed that P. progenetica (Pp), the type species of the genus Paedocypris, has an unusual mtDNA bearing - within its D-loop - a tandem array of a 34-bp repeat sequence called the minifish repeat, which shows compromised replication efficiency in vitro. Here we report that Pp exhibits high genetic variation in mtDNA size. The efficiency of D-loop amplification was found to depend upon primers. Interestingly, Pp individuals of one and the same population differed drastically in mtDNA size resulting from varying copy numbers of the minifish repeat. We conclude that minifish has a high mutation rate and perhaps represents a rapidly evolving taxon of vertebrates.
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Base de datos:
MEDLINE
Asunto principal:
Cipriniformes
/
ADN Mitocondrial
/
Secuencias Repetidas en Tándem
/
Genes Mitocondriales
/
Variaciones en el Número de Copia de ADN
/
Mitocondrias
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Curr Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2014
Tipo del documento:
Article