Baclofen overdose treated with continuous venovenous hemofiltration.
Eur J Clin Pharmacol
; 71(3): 357-61, 2015 Mar.
Article
en En
| MEDLINE
| ID: mdl-25567218
ABSTRACT
PURPOSE:
Overdose with baclofen, a derivative of the inhibitory neurotransmitter γ-aminobutyric acid, may lead to severe respiratory and central nervous system depression and can be life-threatening. Prolonged half-lives of baclofen, of up to 34 h, have been reported in patients after overdose. Hemodialysis has proven to be a successful approach to improve clearance of baclofen, but the value of continuous venovenous hemofiltration (CVVH) is unclear. We applied CVVH in a patient with acute baclofen overdose.METHODS:
Pharmacokinetic measurements of baclofen in serum and hemofiltrate were made at six time points after hospital admission. Baclofen concentration-time data were analyzed using non-compartmental methods, and the relative contribution of clearance by hemofiltration to total baclofen clearance was calculated.RESULTS:
Baclofen concentrations in serum varied between 1.81 and 0.05 mg/L. Concentrations of baclofen in hemofiltrate were within the same range (between 0.74 and 0.05 mg/L), and the elimination half-life during hemofiltration was estimated at 4.8 h. Total clearance and clearance via hemofiltration were estimated at 6.6 and 2.4 L/h, indicating that clearance could be increased by approximately 57 % by applying hemofiltration.CONCLUSIONS:
The presented case demonstrates the usefulness of CVVH in the treatment of baclofen overdose and indicates that CVVH can be used as an alternative to hemodialysis in patients with overdose of baclofen.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Baclofeno
/
Hemofiltración
/
Sobredosis de Droga
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
Eur J Clin Pharmacol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Países Bajos