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Analytical results for cell constriction dominated by bending energy.
Almendro-Vedia, Victor G; Monroy, Francisco; Cao, Francisco J.
Afiliación
  • Almendro-Vedia VG; Departamento de Física Atómica, Molecular y Nuclear, Universidad Complutense de Madrid, 28040 Madrid, Spain.
  • Monroy F; Departamento de Química Física I, Universidad Complutense de Madrid, 28040 Madrid, Spain.
  • Cao FJ; Departamento de Física Atómica, Molecular y Nuclear, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Article en En | MEDLINE | ID: mdl-25679648
Analytical expressions are obtained for the main magnitudes of a symmetrically constricted vesicle. These equations provide an easy and compact way to predict minimal requirements for successful constriction and its main magnitudes. Thus, they can be useful for the design of synthetic divisomes and give good predictions for magnitudes including constriction energy, length of the constriction zone, volume and area of the vesicle, and the stability coefficient for symmetric constriction. The analytical expressions are derived combining a perturbative expansion in the Lagrangian for small deformations with a cosine ansatz in the constriction region. Already the simple fourth-order (or sixth-order) approximation provides a good approximation to the values of the main physical magnitudes during constriction, as we show through comparison with numerical results. Results are for vesicles with negligible effects from spontaneous curvature, surface tension, and pressure differences. This is the case when membrane components generating spontaneous curvature are scarce, membrane trafficking is present with low energetic cost, and the external medium is isotonic.
Asunto(s)
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Base de datos: MEDLINE Asunto principal: División Celular / Fenómenos Mecánicos / Modelos Biológicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Phys Rev E Stat Nonlin Soft Matter Phys Asunto de la revista: BIOFISICA / FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: España
Buscar en Google
Base de datos: MEDLINE Asunto principal: División Celular / Fenómenos Mecánicos / Modelos Biológicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Phys Rev E Stat Nonlin Soft Matter Phys Asunto de la revista: BIOFISICA / FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: España