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Mutant IDH is sufficient to initiate enchondromatosis in mice.
Hirata, Makoto; Sasaki, Masato; Cairns, Rob A; Inoue, Satoshi; Puviindran, Vijitha; Li, Wanda Y; Snow, Bryan E; Jones, Lisa D; Wei, Qingxia; Sato, Shingo; Tang, Yuning J; Nadesan, Puviindran; Rockel, Jason; Whetstone, Heather; Poon, Raymond; Weng, Angela; Gross, Stefan; Straley, Kimberly; Gliser, Camelia; Xu, Yingxia; Wunder, Jay; Mak, Tak W; Alman, Benjamin A.
Afiliación
  • Hirata M; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Sasaki M; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, M5G 2C1;
  • Cairns RA; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, M5G 2C1;
  • Inoue S; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, M5G 2C1;
  • Puviindran V; Department of Orthopedic Surgery, Duke University, Durham, NC 27710;
  • Li WY; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, M5G 2C1;
  • Snow BE; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, M5G 2C1;
  • Jones LD; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, M5G 2C1;
  • Wei Q; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Sato S; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Tang YJ; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Nadesan P; Department of Orthopedic Surgery, Duke University, Durham, NC 27710;
  • Rockel J; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Whetstone H; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Poon R; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Weng A; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4;
  • Gross S; Agios Pharmaceuticals, Cambridge, MA 02139;
  • Straley K; Agios Pharmaceuticals, Cambridge, MA 02139;
  • Gliser C; Agios Pharmaceuticals, Cambridge, MA 02139;
  • Xu Y; Chempartner, Shanghai 201203, China; and.
  • Wunder J; Department of Orthopedic Surgery, Mount Sinai Hospital, Toronto, ON, Canada, M5G 1X5.
  • Mak TW; The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada, M5G 2C1; tmak@uhnres.utoronto.ca benjamin.alman@sickkids.ca.
  • Alman BA; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada, M5G 0A4; Department of Orthopedic Surgery, Duke University, Durham, NC 27710; tmak@uhnres.utoronto.ca benjamin.alman@sickkids.ca.
Proc Natl Acad Sci U S A ; 112(9): 2829-34, 2015 Mar 03.
Article en En | MEDLINE | ID: mdl-25730874
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Condrocitos / Mutación Missense / Encondromatosis / Isocitrato Deshidrogenasa Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / Condrocitos / Mutación Missense / Encondromatosis / Isocitrato Deshidrogenasa Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article