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Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters.
Nguyen, Theresa V; Ukairo, Okechukwu; Khetani, Salman R; McVay, Michael; Kanchagar, Chitra; Seghezzi, Wolfgang; Ayanoglu, Gulesi; Irrechukwu, Onyi; Evers, Raymond.
Afiliación
  • Nguyen TV; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • Ukairo O; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • Khetani SR; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • McVay M; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • Kanchagar C; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • Seghezzi W; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • Ayanoglu G; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • Irrechukwu O; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
  • Evers R; Merck Research Laboratories, Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Rahway, New Jersey (T.V.N., R.E.); Hepregen Corporation, Medford, Massachusetts (O.U., O.I.); Colorado State University, Fort Collins, Colorado (S.R.K.); Agios Pharmaceuticals, Cambridge, Massachusett
Drug Metab Dispos ; 43(5): 774-85, 2015 May.
Article en En | MEDLINE | ID: mdl-25739975
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Interleucinas / Hepatocitos / Inflamación / Macrófagos del Hígado Límite: Adult / Animals / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2015 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Portadoras / Interleucinas / Hepatocitos / Inflamación / Macrófagos del Hígado Límite: Adult / Animals / Humans / Male / Middle aged Idioma: En Revista: Drug Metab Dispos Asunto de la revista: FARMACOLOGIA Año: 2015 Tipo del documento: Article