Transition-metal-free hydration of nitriles using potassium tert-butoxide under anhydrous conditions.
J Org Chem
; 80(8): 4148-51, 2015 Apr 17.
Article
en En
| MEDLINE
| ID: mdl-25786059
ABSTRACT
Potassium tert-butoxide acts as a nucleophilic oxygen source during the hydration of nitriles to give the corresponding amides under anhydrous conditions. The reaction proceeds smoothly for a broad range of substrates under mild conditions, providing an efficient and economically affordable synthetic route to the amides in excellent yields. This protocol does not need any transition-metal catalyst or any special experimental setup and is easily scalable to bulk scale synthesis. A single-electron-transfer radical mechanism as well as an ionic mechanism have been proposed for the hydration process.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Elementos de Transición
/
Butanoles
/
Metales
/
Nitrilos
Idioma:
En
Revista:
J Org Chem
Año:
2015
Tipo del documento:
Article
País de afiliación:
India