Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.
Phytochemistry
; 115: 222-30, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-25800107
ABSTRACT
Eight polyprenylated spirocyclic acylphloroglucinol derivatives (PSAPs), hyperascyrones A-H, were isolated from the aerial parts of Hypericum ascyron Linn., together with six known analogs. Their structures were established by spectroscopic analyses including HRESIMS, 1D and 2D NMR, and their absolute configurations were determined by electronic circular dichroism calculations (ECD, Gaussian 09). Structures of previously reported tomoeones C, D, G, and H were revised. Hyperascyrones A-H were evaluated for their cytotoxic and anti-HIV-1 activities, with hyperascyrones C and G exhibiting significant cytotoxicities against HL-60 cell lines with IC50 values of 4.22 and 8.36 µM, respectively. In addition, the chemotaxonomic significance of these compounds was also discussed.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Floroglucinol
/
Compuestos de Espiro
/
Medicamentos Herbarios Chinos
/
Fármacos Anti-VIH
/
Hypericum
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
Phytochemistry
Año:
2015
Tipo del documento:
Article