Dynamic study of methionine positron emission tomography in patients with glioblastoma with oligodendroglial components.
Brain Tumor Pathol
; 32(4): 253-60, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-25812514
ABSTRACT
Anaplastic oligoastrocytoma (AOA) with necrosis is classified as glioblastoma (GBM) with oligodendroglioma component (GBMO), according to the 2007 World Health Organization classification. The prognosis of GBMO remains controversial because definitive diagnostic criteria regarding the percentage of the oligodendroglial components (OC) in the GBM do not exist. We previously reported dynamic methionine (MET) positron emission tomography (PET) in patients with these tumors. A significant decrease in the MET signal was seen in oligodendrocytic tumors, in contrast to a significant MET increase in GBMs. In this study, we analyzed the dynamic MET PET signal in four patients with primary (n = 2) and secondary (n = 2) GBMOs. Static PET scanning was performed in three consecutive phases. Both cases of primary GBMOs and one case of secondary GBMO presented with a gradual decrease in MET PET signal over the consecutive phases. In contrast, the remaining case of secondary GBMO presented with a pattern of slight increase. It is likely that the dynamic change of MET in patients with GBMO resemble those in patients with oligodendroglial tumor, however, further studies are needed to confirm them. We discuss the mechanisms from a viewpoint of pathological findings.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Encefálicas
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Oligodendroglía
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Glioblastoma
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Tomografía de Emisión de Positrones
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Metionina
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Brain Tumor Pathol
Asunto de la revista:
CEREBRO
/
NEOPLASIAS
/
PATOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Japón