Enzymatic characterization of in vitro-expressed Baikal seal cytochrome P450 (CYP) 1A1, 1A2, and 1B1: implication of low metabolic potential of CYP1A2 uniquely evolved in aquatic mammals.

Iwata, Hisato; Yamaguchi, Keisuke; Takeshita, Yoko; Kubota, Akira; Hirakawa, Shusaku; Isobe, Tomohiko; Hirano, Masashi; Kim, Eun-Young

Iwata, Hisato; Yamaguchi, Keisuke; Takeshita, Yoko; Kubota, Akira; Hirakawa, Shusaku; Isobe, Tomohiko; Hirano, Masashi; Kim, Eun-Young.

Afiliación

Iwata H; Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan. Electronic address: iwatah@agr.ehime-u.ac.jp.
Yamaguchi K; Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
Takeshita Y; Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
Kubota A; Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro 080-8555, Japan.
Hirakawa S; Fukuoka Institute of Health and Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka 818-0135, Japan.
Isobe T; Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan.
Hirano M; Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
Kim EY; Department of Life and Nanopharmaceutical Science and Department of Biology, Kyung Hee University, Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, South Korea. Electronic address: eykim08@khu.ac.kr.

Aquat Toxicol ; 162: 138-151, 2015 May.

Article en En | MEDLINE | ID: mdl-25814058

Asunto(s)

Hidrocarburo de Aril Hidroxilasas/metabolismo; Phocidae/metabolismo; Animales; Biomarcadores/metabolismo; Citocromo P-450 CYP1A1/metabolismo; Citocromo P-450 CYP1A2/metabolismo; Citocromo P-450 CYP1B1/metabolismo; Estrógenos/metabolismo; Femenino; Humanos; Hidroxilación; Hígado/metabolismo; Masculino; Microsomas/metabolismo; Treonina/metabolismo; Contaminación Química del Agua/efectos adversos

Palabras clave

Alkoxyresorufin O-dealkylation; Aquatic mammal; Baikal seal; Conserved threonine; Cytochrome P450; Estrogen hydroxylation

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hidrocarburo de Aril Hidroxilasas / Phocidae Límite: Animals / Female / Humans / Male Idioma: En Revista: Aquat Toxicol Asunto de la revista: BIOLOGIA / TOXICOLOGIA Año: 2015 Tipo del documento: Article

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