Long-term sequelae treatment of peripheral facial paralysis with botulinum toxin type A: Repartition and kinetics of doses used.
Ann Chir Plast Esthet
; 61(1): 10-5, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-25953657
ABSTRACT
STUDY OBJECTIVES:
Botulinum toxin is a key therapeutic tool in the comprehensive treatment of peripheral facial paralysis. It fights spasms, synkinesis and overactivity of the different skin muscles responsible of facial expressions. Even though injection techniques as well as target muscles have been well identified, doses used remain quite imprecise and often not detailed muscle by muscle, further more dosage progression has not been monitored over time. Our retrospective study is the first one to refine the repartition of botulinum toxin doses on each of the relevant skin muscles and assess dosage kinetics. PATIENTS ANDMETHODS:
Thirty patients were included since 2008 with a mean follow-up of 2.3years. Each patient had at least 3 injections, with a delay of 4 to 6months between each injection.RESULTS:
Mean doses are indicated for each muscle injected on the paralyzed and healthy sides. Dose kinetics suggests an initial dosage increase after the first injection followed by a decrease over time. No treatment resistance was observed.CONCLUSION:
Our study represents a didactic help in using botulinum toxin for sequelae of peripheral facial paralysis by providing more details on the effective mean doses for each muscle and their progression over time.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Toxinas Botulínicas Tipo A
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Músculos Faciales
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Parálisis Facial
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Animals
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Chir Plast Esthet
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia