Familial colorectal cancer.
Intern Med J
; 45(5): 482-91, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-25955461
ABSTRACT
Identifying individuals with a genetic predisposition to developing familial colorectal cancer (CRC) is crucial to the management of the affected individual and their family. In order to do so, the physician requires an understanding of the different gene mutations and clinical manifestations of familial CRC. This review summarises the genetics, clinical manifestations and management of the known familial CRC syndromes, specifically Lynch syndrome, familial adenomatous polyposis, MUTYH-associated neoplasia, juvenile polyposis syndrome and Peutz-Jeghers syndrome. An individual suspected of having a familial CRC with an underlying genetic predisposition should be referred to a familial cancer centre to enable pre-test counselling and appropriate follow up.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndromes Neoplásicos Hereditarios
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Síndrome de Peutz-Jeghers
/
Neoplasias Colorrectales
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Neoplasias Colorrectales Hereditarias sin Poliposis
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Poliposis Adenomatosa del Colon
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Predisposición Genética a la Enfermedad
/
Poliposis Intestinal
Tipo de estudio:
Diagnostic_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Intern Med J
Asunto de la revista:
MEDICINA INTERNA
Año:
2015
Tipo del documento:
Article
País de afiliación:
Australia