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The impact of low-frequency and rare variants on lipid levels.
Surakka, Ida; Horikoshi, Momoko; Mägi, Reedik; Sarin, Antti-Pekka; Mahajan, Anubha; Lagou, Vasiliki; Marullo, Letizia; Ferreira, Teresa; Miraglio, Benjamin; Timonen, Sanna; Kettunen, Johannes; Pirinen, Matti; Karjalainen, Juha; Thorleifsson, Gudmar; Hägg, Sara; Hottenga, Jouke-Jan; Isaacs, Aaron; Ladenvall, Claes; Beekman, Marian; Esko, Tõnu; Ried, Janina S; Nelson, Christopher P; Willenborg, Christina; Gustafsson, Stefan; Westra, Harm-Jan; Blades, Matthew; de Craen, Anton J M; de Geus, Eco J; Deelen, Joris; Grallert, Harald; Hamsten, Anders; Havulinna, Aki S; Hengstenberg, Christian; Houwing-Duistermaat, Jeanine J; Hyppönen, Elina; Karssen, Lennart C; Lehtimäki, Terho; Lyssenko, Valeriya; Magnusson, Patrik K E; Mihailov, Evelin; Müller-Nurasyid, Martina; Mpindi, John-Patrick; Pedersen, Nancy L; Penninx, Brenda W J H; Perola, Markus; Pers, Tune H; Peters, Annette; Rung, Johan; Smit, Johannes H; Steinthorsdottir, Valgerdur.
Afiliación
  • Surakka I; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] National Institute for Health and Welfare, Helsinki, Finland.
  • Horikoshi M; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Mägi R; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Sarin AP; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] National Institute for Health and Welfare, Helsinki, Finland.
  • Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Lagou V; 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Marullo L; Department of Life Sciences and Biotechnology, Genetic Section, University of Ferrara, Ferrara, Italy.
  • Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Miraglio B; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Timonen S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Kettunen J; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] National Institute for Health and Welfare, Helsinki, Finland.
  • Pirinen M; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Karjalainen J; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Thorleifsson G; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
  • Hägg S; 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [2] Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. [3] Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Hottenga JJ; Department of Biological Psychology, EMGO Institute for Health and Care Research, VU University and VU University Medical Center, Amsterdam, the Netherlands.
  • Isaacs A; 1] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. [2] Centre for Medical Systems Biology, Leiden, the Netherlands.
  • Ladenvall C; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
  • Beekman M; 1] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. [2] Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands.
  • Esko T; 1] Estonian Genome Center, University of Tartu, Tartu, Estonia. [2] Division of Endocrinology, Children's Hospital, Boston, Massachusetts, USA. [3] Center for Basic and Translational Obesity Research, Children's Hospital, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Br
  • Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Nelson CP; 1] Department of Cardiovascular Sciences, University of Leicester, Leicester, UK. [2] National Institute for Health Research (NIHR) Leicester Cardiovascular Disease Biomedical Research Unit, Glenfield Hospital, Leicester, UK.
  • Willenborg C; 1] Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany. [2] Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Hamburg, Lübeck and Kiel, Germany.
  • Gustafsson S; 1] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [2] Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. [3] Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Westra HJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Blades M; Department of Epidemiology and Biostatistics, Medical Research Council (MRC) Health Protection Agency (HPA), Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
  • de Craen AJ; 1] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
  • de Geus EJ; Department of Biological Psychology, EMGO Institute for Health and Care Research, VU University and VU University Medical Center, Amsterdam, the Netherlands.
  • Deelen J; 1] Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. [2] Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands.
  • Grallert H; 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] German Center for Diabetes Research (DZD), Neuherberg, Germany. [3] Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Envir
  • Hamsten A; Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
  • Havulinna AS; National Institute for Health and Welfare, Helsinki, Finland.
  • Hengstenberg C; 1] Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. [2] Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Munich Heart Alliance, Munich, Germany.
  • Houwing-Duistermaat JJ; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
  • Hyppönen E; 1] Population, Policy and Practice, University College London Institute of Child Health, London, UK. [2] South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia. [3] School of Population Health, University of South Australia, Adelaide, South Australia, Australia.
  • Karssen LC; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
  • Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
  • Lyssenko V; 1] Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden. [2] Steno Diabetes Center, Gentofte, Denmark.
  • Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Müller-Nurasyid M; 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), partner site Munich Heart Alliance, Munich, Germany. [3] Department of Medicine I, University Hospital Groß
  • Mpindi JP; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
  • Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Penninx BW; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
  • Perola M; 1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] National Institute for Health and Welfare, Helsinki, Finland. [3] Estonian Genome Center, University of Tartu, Tartu, Estonia. [4] Diabetes and Obesity Research Program, University of Helsinki, Helsink
  • Pers TH; 1] Division of Endocrinology, Children's Hospital, Boston, Massachusetts, USA. [2] Center for Basic and Translational Obesity Research, Children's Hospital, Boston, Massachusetts, USA. [3] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
  • Peters A; 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [2] Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. [3] Deutsches Herzzentrum Münc
  • Rung J; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK.
  • Smit JH; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
  • Steinthorsdottir V; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Nat Genet ; 47(6): 589-97, 2015 Jun.
Article en En | MEDLINE | ID: mdl-25961943
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Metabolismo de los Lípidos Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Finlandia
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Metabolismo de los Lípidos Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2015 Tipo del documento: Article País de afiliación: Finlandia