[Ursodeoxycholic acid: A therapeutic niche in an internist's practice].
Ter Arkh
; 87(4): 84-90, 2015.
Article
en Ru
| MEDLINE
| ID: mdl-26087640
ABSTRACT
The paper shows more than 40 years' experience with ursodeoxycholic acid (UDCA) used as a drug; during this period it has demonstrated its rather high clinical efficacy. Due to the range of its inherent pleiotropic (choleretic, cytoprotective, immunomodulatory, antiapoptotic, hypocholesterolemic, and litholytic) properties, UDCA has a broad spectrum of therapeutic activity. The paper considers the issues associated with the mechanism of action and with the clinical effects of this bile acid. It gives the results of the most important randomized controlled trials determining currently the evidence base for the efficiency and safety of using UDCA in the clinical picture of visceral diseases.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ácido Ursodesoxicólico
/
Enfermedades Cardiovasculares
/
Investigación Biomédica
/
Enfermedades del Sistema Digestivo
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Medicina Interna
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
Ru
Revista:
Ter Arkh
Año:
2015
Tipo del documento:
Article