Central Administration of the Ciliary Neurotrophic Factor Analogue, Axokine, Does Not Play a Role in Long-Term Energy Homeostasis in Adult Mice.
Neuroendocrinology
; 103(3-4): 223-9, 2016.
Article
en En
| MEDLINE
| ID: mdl-26088805
ABSTRACT
BACKGROUND/AIMS:
Ciliary neurotrophic factor (CNTF) exerts powerful anorectic effects and has been suggested to regulate long-term energy balance by inducing adult neurogenesis in the arcuate nucleus of the hypothalamus.METHODS:
The CNTF analogue, Axokine, was infused into the lateral ventricle of high-fat-fed mice for 1 week. Food intake, energy expenditure, body mass, glucose metabolism, and neurogenesis in the arcuate nucleus (ARC) of the hypothalamus were assessed 3 weeks after cessation of Axokine treatment.RESULTS:
Short-term administration of Axokine induced an anorexic response but did not promote sustained weight loss. Instead, a rapid rebound in food intake and body mass occurred immediately after cessation of Axokine treatment, and this tended to reduce insulin sensitivity. Immunolabeling of 5-bromo-2'-deoxyuridine revealed limited neurogenesis in the ARC 3 weeks after Axokine treatment.CONCLUSION:
These findings suggest that Axokine/CNTF does not induce substantial or sustained ARC neurogenesis or contribute to the long-term regulation of energy balance in mice.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Núcleo Arqueado del Hipotálamo
/
Factor Neurotrófico Ciliar
/
Metabolismo Energético
/
Neurogénesis
Límite:
Animals
Idioma:
En
Revista:
Neuroendocrinology
Año:
2016
Tipo del documento:
Article
País de afiliación:
Australia