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Incidence of Cyclophosphamide-induced Urotoxicity and Protective Effect of Mesna in Rheumatic Diseases.
Yilmaz, Neslihan; Emmungil, Hakan; Gucenmez, Sercan; Ozen, Gulsen; Yildiz, Fatih; Balkarli, Ayse; Kimyon, Gezmis; Coskun, Belkis Nihan; Dogan, Ismail; Pamuk, Omer Nuri; Yasar, Sule; Cetin, Gozde Yildirim; Yazici, Ayten; Ergulu Esmen, Serpil; Cagatay, Yonca; Yilmaz, Sema; Cefle, Ayse; Sayarlioglu, Mehmet; Kasifoglu, Timucin; Karadag, Omer; Pehlivan, Yavuz; Dalkilic, Ediz; Kisacik, Bunyamin; Cobankara, Veli; Erken, Eren; Direskeneli, Haner; Aksu, Kenan; Yavuz, Sule.
Afiliación
  • Yilmaz N; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Emmungil H; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Gucenmez S; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Ozen G; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Yildiz F; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Balkarli A; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Kimyon G; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Coskun BN; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Dogan I; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Pamuk ON; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Yasar S; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Cetin GY; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Yazici A; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Ergulu Esmen S; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Cagatay Y; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Yilmaz S; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Cefle A; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Sayarlioglu M; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Kasifoglu T; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Karadag O; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Pehlivan Y; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Dalkilic E; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Kisacik B; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Cobankara V; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Erken E; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Direskeneli H; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Aksu K; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
  • Yavuz S; From the Rheumatology Department, Faculty of Medicine, Istanbul Bilim University; Rheumatology Department, Faculty of Medicine, Marmara University, Istanbul; Rheumatology Department, Faculty of Medicine, Ege University, Izmir; Rheumatology Department, Faculty of Medicine, Cukurova University, Adana;
J Rheumatol ; 42(9): 1661-6, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26178288
ABSTRACT

OBJECTIVE:

To assess bladder toxicity of cyclophosphamide (CYC) and uroprotective effect of mesna in rheumatic diseases.

METHODS:

Data of 1018 patients (725 women/293 men) treated with CYC were evaluated in this retrospective study. All of the following information was obtained the cumulative CYC dose, route of CYC administration, duration of therapy, concomitant mesna usage, and hemorrhagic cystitis. Cox proportional hazard model was used for statistics.

RESULTS:

We identified 17 patients (1.67%) with hemorrhagic cystitis and 2 patients (0.19%) with bladder cancer in 4224 patient-years. The median time for diagnosis to hemorrhagic cystitis was 10 months (4-48) and bladder cancer was 8 years (6-10.9). There were 583 patients (57.2%) who received mesna with intravenous CYC therapy. We observed similar incidence rate for hemorrhagic cystitis in both patient groups concomitantly treated with or without mesna [9/583 (1.5%) vs 8/425 (1.8%) respectively, p = 0.08]. Cumulative CYC dose (HR for 10-g increments 1.24, p < 0.001) was associated with hemorrhagic cystitis.

CONCLUSION:

Cumulative dose was the only risk factor for hemorrhagic cystitis in patients treated with CYC. No proof was obtained for the uroprotective effect of mesna in our cohort.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Reumáticas / Mesna / Sustancias Protectoras / Ciclofosfamida / Cistitis Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Año: 2015 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Reumáticas / Mesna / Sustancias Protectoras / Ciclofosfamida / Cistitis Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Rheumatol Año: 2015 Tipo del documento: Article