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The promise and peril of chemical probes.
Arrowsmith, Cheryl H; Audia, James E; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E; Brown, Peter J; Bunnage, Mark E; Buser-Doepner, Carolyn; Campbell, Robert M; Carter, Adrian J; Cohen, Philip; Copeland, Robert A; Cravatt, Ben; Dahlin, Jayme L; Dhanak, Dashyant; Edwards, Aled M; Frederiksen, Mathias; Frye, Stephen V; Gray, Nathanael; Grimshaw, Charles E; Hepworth, David; Howe, Trevor; Huber, Kilian V M; Jin, Jian; Knapp, Stefan; Kotz, Joanne D; Kruger, Ryan G; Lowe, Derek; Mader, Mary M; Marsden, Brian; Mueller-Fahrnow, Anke; Müller, Susanne; O'Hagan, Ronan C; Overington, John P; Owen, Dafydd R; Rosenberg, Saul H; Roth, Bryan; Roth, Brian; Ross, Ruth; Schapira, Matthieu; Schreiber, Stuart L; Shoichet, Brian; Sundström, Michael; Superti-Furga, Giulio; Taunton, Jack; Toledo-Sherman, Leticia; Walpole, Chris.
Afiliación
  • Arrowsmith CH; 1] Structural Genomics Consortium, Toronto, Ontario, Canada. [2] Princess Margaret Cancer Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
  • Audia JE; Constellation Pharmaceuticals, Cambridge, Massachusetts, USA.
  • Austin C; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
  • Baell J; Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia.
  • Bennett J; Discovery Chemistry, Merck Research Laboratories, Boston, Massachusetts, USA.
  • Blagg J; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.
  • Bountra C; Structural Genomics Consortium, University of Oxford, Oxford, UK.
  • Brennan PE; 1] Structural Genomics Consortium, University of Oxford, Oxford, UK. [2] Target Discovery Institute, University of Oxford, Oxford, UK.
  • Brown PJ; Structural Genomics Consortium, Toronto, Ontario, Canada.
  • Bunnage ME; Worldwide Medicinal Chemistry, Pfizer, Cambridge, Massachusetts, USA.
  • Buser-Doepner C; GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Campbell RM; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, USA.
  • Carter AJ; Corporate Department Research Networking, Boehringer Ingelheim GmbH, Ingelheim, Germany.
  • Cohen P; The Sir James Black Centre, University of Dundee, Dundee, UK.
  • Copeland RA; Epizyme, Inc., Cambridge, Massachusetts, USA.
  • Cravatt B; Department of Chemical Physiology, Scripps Research Institute, San Diego, California, USA.
  • Dahlin JL; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
  • Dhanak D; Janssen Research and Development, Spring House, Pennsylvania, USA.
  • Edwards AM; Structural Genomics Consortium, Toronto, Ontario, Canada.
  • Frederiksen M; Novartis Institutes for BioMedical Research, Novartis, Basel, Switzerland.
  • Frye SV; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Gray N; Department of Biological Chemistry and Molecular Pharmacology, Harvard University, Cambridge, Massachusetts, USA.
  • Grimshaw CE; Takeda California Inc., San Diego, California, USA.
  • Hepworth D; Worldwide Medicinal Chemistry, Pfizer, Cambridge, Massachusetts, USA.
  • Howe T; Janssen Research and Development, High Wycombe, Bucks, UK.
  • Huber KV; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
  • Jin J; 1] Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [3] Department of Pharmacology and Systems Therapeutics, Icahn School of Medic
  • Knapp S; 1] Structural Genomics Consortium, University of Oxford, Oxford, UK. [2] Target Discovery Institute, University of Oxford, Oxford, UK.
  • Kotz JD; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
  • Kruger RG; Cancer Epigenetics, GlaxoSmithKline, Collegeville, Pennsylvania, USA.
  • Lowe D; Vertex Pharmaceuticals, Boston, Massachusetts, USA.
  • Mader MM; Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana, USA.
  • Marsden B; Structural Genomics Consortium, University of Oxford, Oxford, UK.
  • Mueller-Fahrnow A; Bayer Pharma AG, Berlin, Germany.
  • Müller S; 1] Structural Genomics Consortium, University of Oxford, Oxford, UK. [2] Target Discovery Institute, University of Oxford, Oxford, UK.
  • O'Hagan RC; Oncology Discovery, Merck Research Laboratories, Boston, Massachusetts, USA.
  • Overington JP; 1] European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK. [2] Stratified Medical, London, UK.
  • Owen DR; Worldwide Medicinal Chemistry, Pfizer, Cambridge, Massachusetts, USA.
  • Rosenberg SH; AbbVie, North Chicago, Illinois, USA.
  • Roth B; The National Institute of Mental Health Psychoactive Active Drug Screening Program (NIMH PDSP), Department of Pharmacology, The University of North Carolina Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School
  • Roth B; UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • Ross R; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Schapira M; 1] Structural Genomics Consortium, Toronto, Ontario, Canada. [2] Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.
  • Schreiber SL; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
  • Shoichet B; School of Pharmacy, University of California-San Francisco, San Francisco, California, USA.
  • Sundström M; 1] Structural Genomics Consortium, Karolinska Institutet, Solna, Sweden. [2] Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Solna, Sweden.
  • Superti-Furga G; 1] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. [2] Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
  • Taunton J; 1] Department of Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, California, USA. [2] Howard Hughes Medical Institute, University of California-San Francisco, San Francisco, California, USA.
  • Toledo-Sherman L; CHDI Management/CHDI Foundation, Los Angeles, California, USA.
  • Walpole C; Structural Genomics Consortium, McGill University, Montreal, Quebec, Canada.
Nat Chem Biol ; 11(8): 536-41, 2015 Aug.
Article en En | MEDLINE | ID: mdl-26196764
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sondas Moleculares / Difusión de la Información / Investigación Biomédica / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Canadá
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sondas Moleculares / Difusión de la Información / Investigación Biomédica / Bibliotecas de Moléculas Pequeñas Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Canadá