Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus.
Mar Drugs
; 13(7): 4171-8, 2015 Jul 07.
Article
en En
| MEDLINE
| ID: mdl-26198234
ABSTRACT
One new bicyclic lactam, cladosporilactam A (1), and six known 12-membered macrolides (2-7) were isolated from a gorgonian-derived Cladosporium sp. fungus collected from the South China Sea. Their complete structural assignments were elucidated by comprehensive spectroscopic investigation. Quantum chemistry calculations were used in support of the structural determination of 1. The absolute configuration of 1 was determined by calculation of its optical rotation. Cladosporilactam A (1) was the first example of 7-oxabicyclic[6.3.0]lactam obtained from a natural source. Compound 1 exhibited promising cytotoxic activity against cervical cancer HeLa cell line with an IC50 value of 0.76 µM.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ascomicetos
/
Macrólidos
/
Compuestos Bicíclicos Heterocíclicos con Puentes
/
Lactamas Macrocíclicas
/
Organismos Acuáticos
/
Lactamas
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mar Drugs
Asunto de la revista:
BIOLOGIA
/
FARMACOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China