Impact of co-existent thyroiditis on clinical outcome in papillary thyroid carcinoma with high preoperative serum antithyroglobulin antibody: a retrospective cohort study.
Clin Otolaryngol
; 41(4): 358-64, 2016 Aug.
Article
en En
| MEDLINE
| ID: mdl-26283460
ABSTRACT
OBJECTIVES:
The aim of this study was to investigate the impact of co-existent chronic lymphocytic thyroiditis (CLT) on changes in serum antithyroglobulin antibody (TgAb) and clinical outcome in papillary thyroid carcinoma (PTC) patients with high preoperative serum TgAb.DESIGN:
A retrospective cohort study.SETTING:
University teaching hospital.PARTICIPANTS:
Thirty-seven PTC patients with high preoperative serum TgAb level (≥100 U/mL) were evaluated. All patients underwent total thyroidectomy followed by high-dose I-131 ablation. MAIN OUTCOMEMEASURES:
Per cent changes of TgAb between pre-treatment and post-treatment, and disease-free survival were calculated.RESULTS:
Twenty-two patients (59.5%) had co-existent CLT, and seven had residual/recurrent tumours. There was a higher proportion of females among the patients with CLT compared to those without CLT (95.5% versus 66.7%; P = 0.0306). There were trends towards more aggressive pathologies, such as tumour size, extrathyroidal extension, surgical margin and lymph node stage, in PTC without CLT than in that with co-existent CLT. Pre-treatment and post-treatment TgAb were all higher in PTC with co-existent CLT. But, per cent changes of TgAb between pre-treatment and post-treatment were no significant difference between PTC with and without CLT (P < 0.05). Patients with co-existent CLT showed a significantly lower residual/recurrent tumour rate than those without CLT (4.5% versus 40%; P = 0.0113).CONCLUSION:
Residual/recurrent tumour rate was lower in PTC patients with co-existent CLT than in those without CLT.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Autoanticuerpos
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Neoplasias de la Tiroides
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Carcinoma Papilar
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Enfermedad de Hashimoto
Tipo de estudio:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Otolaryngol
Asunto de la revista:
OTORRINOLARINGOLOGIA
Año:
2016
Tipo del documento:
Article