Are presynaptic GABA-Cρ2 receptors involved in anti-nociception?
Neurosci Lett
; 606: 145-50, 2015 Oct 08.
Article
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| MEDLINE
| ID: mdl-26327143
ABSTRACT
We investigated the anti-nociceptive effects of GABA-C receptors in the central nervous system. Intracisternal injection of CACA, a GABA-C receptor agonist or isoguvacine, a GABA-A receptor agonist, significantly increased the tail-withdrawal latency. TPMPA, a GABA-C receptor antagonist blocked the effects of CACA but not isoguvacine indicating that GABA-C receptors are involved in regulating pain. Further, double-labelled immunofluorescence studies revealed that GABA-Cρ2 receptors are expressed presynaptically in the spinal dorsal horn, especially, substantia gelatinosa, a region that has been previously implicated in analgesia by regulating nociceptive inflow. These data provide a provenance for future work looking at presynaptic spinal GABA-C receptors in the control of nociception.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Receptores Presinapticos
/
Receptores de GABA-A
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2015
Tipo del documento:
Article
País de afiliación:
Canadá