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The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study.
Nemoto, O; Furue, M; Nakagawa, H; Shiramoto, M; Hanada, R; Matsuki, S; Imayama, S; Kato, M; Hasebe, I; Taira, K; Yamamoto, M; Mihara, R; Kabashima, K; Ruzicka, T; Hanifin, J; Kumagai, Y.
Afiliación
  • Nemoto O; Kojinkai, Kita13-Jo Naika-Hifuka Clinic, Hokkaido, Japan.
  • Furue M; Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Nakagawa H; Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.
  • Shiramoto M; Medical Co. LTA Hakata Clinic, Fukuoka, Japan.
  • Hanada R; Medical Co. LTA Sumida Hospital, Tokyo, Japan.
  • Matsuki S; Medical Co. LTA Kyushu Clinical Pharmacology Research Clinic, Fukuoka, Japan.
  • Imayama S; Medical Co. LTA Kyushu Clinical Pharmacology Research Clinic, Fukuoka, Japan.
  • Kato M; Kojinkai, Kita13-Jo Naika-Hifuka Clinic, Hokkaido, Japan.
  • Hasebe I; Kojinkai, Kita13-Jo Naika-Hifuka Clinic, Hokkaido, Japan.
  • Taira K; Medical Co. LTA Kyushu Clinical Pharmacology Research Clinic, Fukuoka, Japan.
  • Yamamoto M; Translational Clinical Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
  • Mihara R; Translational Clinical Research Division, Chugai Pharmaceutical Co., Ltd., Tokyo, Japan.
  • Kabashima K; Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Ruzicka T; Department of Dermatology and Allergology, Ludwig-Maximilian-University Munich, Munich, Germany.
  • Hanifin J; Department of Dermatology, Oregon Health and Science University, Portland, OR, U.S.A.
  • Kumagai Y; Kitasato University School of Medicine, Kitasato Clinical Research Center, Kanagawa, Japan.
Br J Dermatol ; 174(2): 296-304, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26409172
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores de Interleucina / Dermatitis Atópica / Anticuerpos Monoclonales Humanizados / Antiinflamatorios Tipo de estudio: Clinical_trials / Etiology_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Br J Dermatol Año: 2016 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores de Interleucina / Dermatitis Atópica / Anticuerpos Monoclonales Humanizados / Antiinflamatorios Tipo de estudio: Clinical_trials / Etiology_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Br J Dermatol Año: 2016 Tipo del documento: Article País de afiliación: Japón