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A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women.
Storniolo, C E; Casillas, R; Bulló, M; Castañer, O; Ros, E; Sáez, G T; Toledo, E; Estruch, R; Ruiz-Gutiérrez, V; Fitó, M; Martínez-González, M A; Salas-Salvadó, J; Mitjavila, M T; Moreno, J J.
Afiliación
  • Storniolo CE; Department of Physiology, University of Barcelona, Barcelona, Spain.
  • Casillas R; Department of Physiology, University of Barcelona, Barcelona, Spain.
  • Bulló M; Human Nutrition Unit, HSPV, Rovira i Virgili University, Reus, Spain.
  • Castañer O; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
  • Ros E; Cardiovascular Risk and Nutrition Research Group, IMIM-Institut de Recerca Hospital del Mar, Barcelona, Spain.
  • Sáez GT; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
  • Toledo E; Endocrinology and Nutrition Service, Hospital Clinic, Barcelona, Spain.
  • Estruch R; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
  • Ruiz-Gutiérrez V; Department of Biochemistry and Molecular Biology, Clinical Analysis Service-CDB HGUV, University of Valencia, Valencia, Spain.
  • Fitó M; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
  • Martínez-González MA; Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
  • Salas-Salvadó J; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
  • Mitjavila MT; Department of Internal Medicine, University of Barcelona, Barcelona, Spain.
  • Moreno JJ; Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.
Eur J Nutr ; 56(1): 89-97, 2017 Feb.
Article en En | MEDLINE | ID: mdl-26450601
PURPOSE: Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control. METHODS: Non-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured. RESULTS: Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP. CONCLUSIONS: The changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Biomarcadores / Dieta Mediterránea / Aceite de Oliva / Hipertensión / Nueces Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2017 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Biomarcadores / Dieta Mediterránea / Aceite de Oliva / Hipertensión / Nueces Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2017 Tipo del documento: Article País de afiliación: España