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The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A.
Vijayakrishnan, Jayaram; Henrion, Marc; Moorman, Anthony V; Fiege, Bettina; Kumar, Rajiv; da Silva Filho, Miguel Inacio; Holroyd, Amy; Koehler, Rolf; Thomsen, Hauke; Irving, Julie A; Allan, James M; Lightfoot, Tracy; Roman, Eve; Kinsey, Sally E; Sheridan, Eamonn; Thompson, Pamela D; Hoffmann, Per; Nöthen, Markus M; Mühleisen, Thomas W; Eisele, Lewin; Bartram, Claus R; Schrappe, Martin; Greaves, Mel; Hemminki, Kari; Harrison, Christine J; Stanulla, Martin; Houlston, Richard S.
Afiliación
  • Vijayakrishnan J; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.
  • Henrion M; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.
  • Moorman AV; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Fiege B; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
  • Kumar R; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
  • da Silva Filho MI; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
  • Holroyd A; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.
  • Koehler R; Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
  • Thomsen H; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
  • Irving JA; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Allan JM; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Lightfoot T; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom.
  • Roman E; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, United Kingdom.
  • Kinsey SE; Department of Paediatric and Adolescent Haematology and Oncology, Leeds General Infirmary, Leeds, United Kingdom.
  • Sheridan E; Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom.
  • Thompson PD; Leeds Institute of Molecular Medicine, University of Leeds, Leeds, United Kingdom.
  • Hoffmann P; Paediatric and Familial Cancer, Institute of Cancer Sciences, Manchester, United Kingdom.
  • Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Mühleisen TW; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
  • Eisele L; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Bartram CR; Genomic Imaging Group, Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Juelich, Germany.
  • Schrappe M; Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Greaves M; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  • Hemminki K; Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.
  • Harrison CJ; General Paediatrics, University Hospital Schleswig-Holstein, Kiel, Germany.
  • Stanulla M; Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey, United Kingdom.
  • Houlston RS; Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany.
Sci Rep ; 5: 15065, 2015 Oct 14.
Article en En | MEDLINE | ID: mdl-26463672
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 9 / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Predisposición Genética a la Enfermedad / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 9 / Inhibidor p16 de la Quinasa Dependiente de Ciclina / Predisposición Genética a la Enfermedad / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Sci Rep Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido