Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome.
Oral Dis
; 22(2): 123-31, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26575180
ABSTRACT
OBJECTIVE:
Patients with burning mouth syndrome (BMS) often represent a clinical challenge as available agents for symptomatic treatment are few and often ineffective. The aim was to evaluate the effect of a bupivacaine lozenge on oral mucosal pain, xerostomia, and taste alterations in patients with BMS.METHODS:
Eighteen patients (4 men and 14 women) aged 39-71 years with BMS were included in this randomized, double-blinded, placebo-controlled, crossover trial. Lozenges (containing bupivacaine or placebo) were administrated three times a day for 2 weeks for two separate treatment periods. Assessment of oral mucosal pain, xerostomia, and taste alterations was performed in a patient diary on a visual analog scale (ranging from 0 to 100 mm) before and after the lozenge was dissolved.RESULTS:
The bupivacaine lozenge significantly reduced the burning oral pain (P < 0.001), increased the sense of taste disturbances (P < 0.001), and had no impact on xerostomia, when adjusted for the treatment period.CONCLUSIONS:
Our results indicate that the bupivacaine lozenge offers a novel therapeutic modality to patients with BMS, although without alleviating effect on the associated symptoms, taste alterations, and xerostomia.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Bupivacaína
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Síndrome de Boca Ardiente
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Anestésicos Locales
/
Mucosa Bucal
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Etiology_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Oral Dis
Asunto de la revista:
ODONTOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Dinamarca