RAG Off-Target Activity Is in the Loop.
Trends Mol Med
; 21(12): 733-735, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26602761
ABSTRACT
The 'off-target' activity of RAG recombinases contributes to mutations and cancer. Recent studies show that the influence of DNA regulatory elements is largely constrained by the formation of chromatin loops and interaction frequencies. Now, the Alt lab has identified major RAG off-target activity bearing similar limitations, with joining events restricted to convergent paired RSS elements in loop domains.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Recombinasas
/
Recombinación V(D)J
Límite:
Animals
Idioma:
En
Revista:
Trends Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos