From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

Aurelio, Luigi; Scullino, Carmen V; Pitman, Melissa R; Sexton, Anna; Oliver, Victoria; Davies, Lorena; Rebello, Richard J; Furic, Luc; Creek, Darren J; Pitson, Stuart M; Flynn, Bernard L

Aurelio, Luigi; Scullino, Carmen V; Pitman, Melissa R; Sexton, Anna; Oliver, Victoria; Davies, Lorena; Rebello, Richard J; Furic, Luc; Creek, Darren J; Pitson, Stuart M; Flynn, Bernard L.

Afiliación

Aurelio L; Monash Institute of Pharmaceutical Science, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia.
Scullino CV; Monash Institute of Pharmaceutical Science, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia.
Pitman MR; Centre for Cancer Biology, University of South Australia and SA Pathology , Frome Road, Adelaide South Australia 5000, Australia.
Sexton A; Monash Institute of Pharmaceutical Science, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia.
Oliver V; Monash Institute of Pharmaceutical Science, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia.
Davies L; Centre for Cancer Biology, University of South Australia and SA Pathology , Frome Road, Adelaide South Australia 5000, Australia.
Rebello RJ; Cancer Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Clayton, Victoria 3800, Australia.
Furic L; Cancer Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Clayton, Victoria 3800, Australia.
Creek DJ; Monash Institute of Pharmaceutical Science, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia.
Pitson SM; Centre for Cancer Biology, University of South Australia and SA Pathology , Frome Road, Adelaide South Australia 5000, Australia.
Flynn BL; Monash Institute of Pharmaceutical Science, Monash University , 381 Royal Parade, Parkville, Victoria 3052, Australia.

J Med Chem ; 59(3): 965-84, 2016 Feb 11.

Article en En | MEDLINE | ID: mdl-26780304

Asunto(s)

Antineoplásicos/farmacología; Inhibidores Enzimáticos/farmacología; Oxidorreductasas/antagonistas & inhibidores; Fosfotransferasas (Aceptor de Grupo Alcohol)/antagonistas & inhibidores; Tiazoles/farmacología; Antineoplásicos/síntesis química; Antineoplásicos/química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Humanos; Estructura Molecular; Oxidorreductasas/metabolismo; Fosfotransferasas (Aceptor de Grupo Alcohol)/metabolismo; Relación Estructura-Actividad; Tiazoles/síntesis química; Tiazoles/química

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Oxidorreductasas / Tiazoles / Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores Enzimáticos / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Australia

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google