Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients.
Blood Cancer J
; 6: e397, 2016 Feb 26.
Article
en En
| MEDLINE
| ID: mdl-26918361
ABSTRACT
We employed a customized Multiple Myeloma (MM)-specific Mutation Panel (M(3)P) to screen a homogenous cohort of 142 untreated MM patients for relevant mutations in a selection of disease-specific genes. M(3)Pv2.0 includes 77 genes selected for being either actionable targets, potentially related to drug-response or part of known key pathways in MM biology. We identified mutations in potentially actionable genes in 49% of patients and provided prognostic evidence of STAT3 mutations. This panel may serve as a practical alternative to more comprehensive sequencing approaches, providing genomic information in a timely and cost-effective manner, thus allowing clinically oriented variant screening in MM.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Variaciones en el Número de Copia de ADN
/
Secuenciación de Nucleótidos de Alto Rendimiento
/
Mieloma Múltiple
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Mutación
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Blood Cancer J
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos