NADPH oxidase 4 contributes to connective tissue growth factor expression through Smad3-dependent signaling pathway.

Liu, Xin-Hua; Zhang, Qiu-Yan; Pan, Li-Long; Liu, Si-Yu; Xu, Peng; Luo, Xiao-Ling; Zou, Si-Li; Xin, Hong; Qu, Le-Feng; Zhu, Yi-Zhun

Liu, Xin-Hua; Zhang, Qiu-Yan; Pan, Li-Long; Liu, Si-Yu; Xu, Peng; Luo, Xiao-Ling; Zou, Si-Li; Xin, Hong; Qu, Le-Feng; Zhu, Yi-Zhun.

Afiliación

Liu XH; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.
Zhang QY; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.
Pan LL; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.
Liu SY; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.
Xu P; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.
Luo XL; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.
Zou SL; Department of Vascular Surgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China.
Xin H; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China.
Qu LF; Department of Vascular Surgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. Electronic address: qulefengsubmit@163.com.
Zhu YZ; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, 826, Zhangheng Road, Pudong New District, Shanghai 201203, China; School of Pharmacy, Macau University of Science and Technology, Macau. Electronic address: zhuyz@fudan.edu.cn.

Free Radic Biol Med ; 94: 174-84, 2016 05.

Article en En | MEDLINE | ID: mdl-26945889

Asunto(s)

Factor de Crecimiento del Tejido Conjuntivo/metabolismo; Músculo Liso Vascular/metabolismo; NADPH Oxidasa 4/metabolismo; Proteína smad3/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo; Animales; Factor de Crecimiento del Tejido Conjuntivo/genética; Regulación de la Expresión Génica; Humanos; Ratones; NADPH Oxidasa 4/genética; Compuestos Onio/farmacología; ARN Interferente Pequeño/genética; Ratas; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/genética; Proteína smad3/genética; Factor de Crecimiento Transformador beta1/genética; Remodelación Vascular/genética

Palabras clave

Connective tissue growth factor; NADPH oxidase 4; Smad 3; Vascular remodeling; Vascular smooth muscle cell

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteína smad3 / Factor de Crecimiento Transformador beta1 / Factor de Crecimiento del Tejido Conjuntivo / NADPH Oxidasa 4 / Músculo Liso Vascular Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: China

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