Complement C5 Inhibition Reduces T Cell-Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice.

Qin, L; Li, G; Kirkiles-Smith, N; Clark, P; Fang, C; Wang, Y; Yu, Z-X; Devore, D; Tellides, G; Pober, J S; Jane-Wit, D

Qin, L; Li, G; Kirkiles-Smith, N; Clark, P; Fang, C; Wang, Y; Yu, Z-X; Devore, D; Tellides, G; Pober, J S; Jane-Wit, D.

Afiliación

Qin L; Department of Surgery, Yale School of Medicine, New Haven, CT.
Li G; Department of Surgery, Yale School of Medicine, New Haven, CT.
Kirkiles-Smith N; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Clark P; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Fang C; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Wang Y; Alexion Pharmaceuticals Inc., New Haven, CT.
Yu ZX; Alexion Pharmaceuticals Inc., New Haven, CT.
Devore D; Alexion Pharmaceuticals Inc., New Haven, CT.
Tellides G; Department of Surgery, Yale School of Medicine, New Haven, CT.
Pober JS; Department of Immunobiology, Yale School of Medicine, New Haven, CT.
Jane-Wit D; Department of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT.

Am J Transplant ; 16(10): 2865-2876, 2016 10.

Article en En | MEDLINE | ID: mdl-27104811

Asunto(s)

Complemento C5/antagonistas & inhibidores; Isoanticuerpos/inmunología; Daño por Reperfusión/complicaciones; Linfocitos T/inmunología; Enfermedades Vasculares/prevención & control; Aloinjertos; Animales; Anticuerpos Monoclonales/farmacología; Células Cultivadas; Activación de Complemento; Humanos; Ratones; Ratones SCID; FN-kappa B/metabolismo; Enfermedades Vasculares/etiología

Palabras clave

alloantibody; basic (laboratory) research/science; complement biology; fusion proteins and monoclonal antibodies; immunobiology; immunosuppressant; immunosuppression/immune modulation; ischemia reperfusion injury (IRI); organ transplantation in general; translational research/science; vasculopathy

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedades Vasculares / Complemento C5 / Linfocitos T / Daño por Reperfusión / Isoanticuerpos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2016 Tipo del documento: Article

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