Micafungin as primary antifungal prophylaxis in patients presenting with acute myeloid leukemia.
Med Mal Infect
; 46(4): 226-9, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-27126350
ABSTRACT
OBJECTIVE:
To study the efficacy and safety of micafungin for prophylaxis of invasive fungal infections in patients undergoing induction chemotherapy for acute myeloid leukemia. PATIENTS ANDMETHODS:
A prospective observational single-center study of 41 patients from the hematology department between May 2012 and April 2015. Micafungin was administered once daily from the first day of induction chemotherapy to the end of the neutropenic phase.RESULTS:
Neither Candida nor Aspergillus infection was documented in our 41 patients from the first day of micafungin infusion to the end of the neutropenic phase. Patients were followed for three months after discontinuation of micafungin and none of them contracted an invasive fungal infection. Only one patient presented with grade III-IV hepatic and ionic toxicities.CONCLUSION:
Micafungin is associated with a good safety profile and is an interesting option for preventing invasive fungal infections in the high-risk population of patients presenting with hematological disorders.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
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Equinocandinas
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Lipopéptidos
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Micosis
/
Antifúngicos
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Med Mal Infect
Año:
2016
Tipo del documento:
Article
País de afiliación:
Francia