Impaired NK cells' activity and increased numbers of CD4 + CD25+ regulatory T cells in multidrug-resistant Mycobacterium tuberculosis patients.
Tuberculosis (Edinb)
; 98: 13-20, 2016 05.
Article
en En
| MEDLINE
| ID: mdl-27156613
ABSTRACT
Multidrug-resistant tuberculosis (MDR-TB) often causes persistent infection and chemotherapy failure, which brings heavy burden of society and family. Many immune cell subsets and regulatory mechanisms may operate throughout the various stages of infection. The presence of regulatory T cells (Tregs) is thought to be an important mechanism that TB successfully evades the immune system. Tregs play a central role in the prevention of autoimmunity and in the control of immune responses. The role of Tregs in MDR-TB infection and persistence is inadequately documented. The current study was designed to determine whether CD4 + CD25+ regulatory T cells may modulate innate immunity (such as NK cells) against human tuberculosis. Our results indicated that the numbers of CD4 + CD25+ Treg cells increased in MDR-TB patients' blood, and the cytokine production of IL-10 increased from MDR-patients compared with healthy subjects, along with the lower activity and low CD69 expression of NK cells in patients. These results suggested that immunity to MDR-TB patients induced circulating CD4 + CD25+ T regulatory cells expansion, which may be related to the persistence of Mycobacterium tuberculosis (M. tb) infection, and to the balance between effectors immune responses and suppression immune responses.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Células Asesinas Naturales
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Linfocitos T Reguladores
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Tuberculosis Resistente a Múltiples Medicamentos
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Subunidad alfa del Receptor de Interleucina-2
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Mycobacterium tuberculosis
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Idioma:
En
Revista:
Tuberculosis (Edinb)
Año:
2016
Tipo del documento:
Article