4E-BP2 hardwires lymphocytes for rapamycin sensitivity.
Sci Signal
; 9(430): fs10, 2016 05 31.
Article
en En
| MEDLINE
| ID: mdl-27245610
ABSTRACT
The mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] inhibitor rapamycin is a potent inhibitor of T and B lymphocyte growth and proliferation. In this issue of Science Signaling, So et al found that the isoform of 4E-BP (4E-BP2) in lymphocytes that regulates messenger RNA translation is more sensitive to the effects of rapamycin than is the 4E-BP isoform found in nonlymphoid cells. Furthermore, inhibition of 4E-BP2 blocks both the growth and proliferation of lymphocytes.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Sirolimus
/
Factor 4E Eucariótico de Iniciación
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Sci Signal
Asunto de la revista:
CIENCIA
/
FISIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos